How does a drug test work? Here's what you need to know (2024)

As substance use disorder continues to be a major public health issue, drug testing has become a standard practice for purposes ranging from pre-employment screening to court-ordered monitoring. Here’s a look at how drug tests work and what you can expect if you need to take one.

What exactly is a drug test?

A drug test checks for the presence of drugs and their metabolites in your system. Metabolites are the substances left behind after the body breaks down drugs. The most common sample types used for drug tests are urine, blood, hair and saliva.

After you provide a drug test sample, it is sent to a lab for analysis. Initial drug screenings are performed using a method called immunoassay, which is a test that uses antibodies to detect the presence of drugs and their metabolites. While this screening doesn’t measure how much of a drug was used, it can indicate the presence or absence of drugs in the system. If screening indicates a presumptive positive for that drug, a second confirmation test is performed to confirm the positive results and provide the most accurate result.

What sample types are used for drug testing?

Drugs and their metabolites get stored in the body in different ways. For example, marijuana metabolites get stored in fat cells and are slowly released over time into urine. Other drugs like cocaine can be detected in urine for only a few days after use. Hair testing can detect drug use over a longer time, since trace amounts in the bloodstream get deposited into growing hair strands.

Some of the most common sample types used for drug testing include:

  • Urine: The most frequently used sample type. A urine drug test can detect recent drug use. The test requires providing a urine sample into a collection cup
  • Blood: Not as common as urine tests but can detect very recent drug use. The test requires having blood drawn by a medical professional
  • Hair: Used to detect longer-term drug use. The test requires snipping a small hair sample near the scalp
  • Saliva: Checks for very recent drug use. The test requires swabbing of the inside of the mouth

What drugs are included in drug test panels?

Many drug tests use a six-panel or expanded 11-panel test to check for multiple commonly used drugs. Certain drugs can stay in your system longer than others, so if you’re checking for the presence of a specific drug, it’s important to know how long that drug is detectable in your system.

A six-panel drug test typically tests for the drugs listed below. The times listed in parentheses indicate how long the drug metabolites may be detectable in urine.

  • Amphetamines like speed and methamphetamine (up to 2 days)
  • Cannabinoids like marijuana or THC (2-7 days for single use, 1-2 months for chronic use)
  • Cocaine (up to 4 days)
  • Opiates like morphine, hydrocodone or codeine (2-7 days depending on the opiate)
  • Oxycodone (1-4 days)
  • Phencyclidine or PCP (14 days for single use, up to 30 days for chronic use)


An expanded 11-panel adds tests for:

  • Barbiturates (2 days to 3 weeks)
  • Benzodiazepines like alprazolam or diazepam (up to 6 weeks)
  • Fentanyl (1-3 days)
  • MDMA or ecstasy (up to 2 days)
  • Methadone (about 3 days)

Preparing for and taking a drug test

There is no standard preparation for a drug test other than having a form of identification with you and being ready to provide a sample. However, it is recommended that you inform your testing professional of any over-the-counter medications or supplements you may be taking, as they may affect your test results. Avoiding foods with poppy seeds is also recommended, as they can be detected as a false positive for opiates in a drug test.

Results are usually available within 1-5 days. A positive result means the drug or metabolite was detected in your system. A negative result means drugs weren’t detected but does not mean there are no drugs present in your system. Following up with a healthcare professional is the best way to confirm your results.

Test your drug exposure with Labcorp OnDemand

Labcorp OnDemand offers multiple options for someone seeking drug testing for personal use or peace of mind. Our Standard Drug Test checks for six common drugs of abuse, and our Complete Drug Test is an expanded 11-panel test. Both require urine samples that must be collected in person at a Labcorp patient service center.

Convenient and reliable drug testing services can give you the insights you need into your drug exposure.

How does a drug test work? Here's what you need to know (2024)

FAQs

How does a drug test work? Here's what you need to know? ›

A drug test screens for certain drugs and/or their metabolites in a biological sample (such as urine or blood). The metabolic processes happen at different speeds for different drugs. Because of this, each drug and its metabolites have a different timeframe in which a drug test can detect them.

What exactly shows up on a drug test? ›

Drug tests commonly test for:
  • Alcohol.
  • Amphetamines, including methamphetamine.
  • Barbiturates, such as phenobarbital and secobarbital.
  • Benzodiazepines, such as alprazolam or clonazepam.
  • Cocaine.
  • Marijuana (THC)
  • Opioids and opiates, such as heroin, codeine, oxycodone, morphine, hydrocodone, and fentanyl.
  • Phencyclidine (PCP)
Jun 7, 2022

What is checked during a drug test? ›

Tests are commonly used for five categories of drugs: Amphetamines; Cocaine; Marijuana; Opiates; and Phencyclidine (PCP). Additional categories may include barbiturates, Benzodiazepines, ethanol (alcohol), hydrocodone, MDMA, methadone, methaqualone, or propoxyphene.

What are the things to consider when doing drug test? ›

The following are tips for preparing for a drug screening:
  • Learn about the process. Knowing the process of a drug screening is the first step in preparation. ...
  • Learn the company's policy. ...
  • Abstain from substance use. ...
  • Hydrate. ...
  • Avoid certain foods and vitamins. ...
  • Bring your valid identification and paperwork.

What will mess up a urine test? ›

(such as coffee, green tea, and black tea) at least before 2 hours of sample collection. test for commercially available test-masking chemicals. Most household substances, such as bleach, salt, or vinegar, will radically alter the pH of your urine, which will make it obvious that you have tampered with the sample.

How long does it take for a drug to be eliminated from the body? ›

Most drugs of abuse stay in the body for at least a few days after the last use and are traceable with urine tests. Opioids like heroin and oxycodone are detectable for between 1 and 3 days after last use. Stimulants including cocaine, meth, and ADHD medications are detectable for about 2 or 3 days.

What determines if you fail a drug test? ›

Here are several situations that may result in a failed drug test. Drug or alcohol consumption can produce a positive test. Medications, such as antidepressants, NSAIDs, and decongestants may result in a false positive. Foods like hemp seeds, poppy seeds, and coca tea can trigger a false positive.

What is the most common false positive drug test? ›

Amphetamine (more on this below) and methamphetamine are the most commonly reported false positive.

What all can a urine test detect? ›

The results of a urine test may indicate the presence of:
  • Diabetes or prediabetes.
  • Chronic kidney disease.
  • Kidney or bladder stones.
  • Kidney or bladder cancer.
  • Bacterial or yeast infections.
  • A urinary tract disorder.
  • Sexually transmitted infections (STIs)
  • Liver or bile duct damage.

What should I avoid before a 10-panel drug test? ›

For 24 hours prior to collecting the specimen, you should avoid strenuous exercise as well as the following substances and drugs:
  • Acetaminophen.
  • Alcohol.
  • Antihistamines.
  • Aspirin.
  • Caffeine.
  • Vitamin B.

What should you not do before a urine sample? ›

How To Prepare
  • Before the test, don't eat foods that can change the colour of your urine. Examples of these include blackberries, beets, and rhubarb.
  • Don't do heavy exercise before the test.
  • Tell your doctor ALL the medicines and natural health products you take. Some may increase the risk of problems during your test.

What will interfere with a drug test? ›

What Can Cause a False Positive Drug Test
  • Secondhand Marijuana Smoke. 1/11. If you hang out often with someone who puffs on pot, your urine could have traces of THC. ...
  • Weight Loss Pills. 2/11. ...
  • Poppy Seeds. 3/11. ...
  • Mouthwash. 4/11. ...
  • Antidepressants. 5/11. ...
  • Antibiotics. 6/11. ...
  • CBD Oil. 7/11. ...
  • Antihistamines. 8/11.
Aug 22, 2023

How far back does a urine test go? ›

In general, the detection time is longest in hair, followed by urine and oral fluid. Drugs in hair may be detectable for up to 90 days, whereas drugs in urine are generally detectable for one to seven days (or longer in chronic users) and in oral fluid from five to 48 hours.

What should never be found in urine? ›

Usually, glucose, ketones, protein, and bilirubin are not detectable in urine.

Can sperm ruin a urine test? ›

In humans, sem*n contamination has been shown to alter measured urine protein concentrations.

What Cannot be detected in a urine test? ›

Psychedelic drugs are extremely difficult to test for, if not impossible. They are never included on urinalysis instant drug tests. These include but are not limited to drugs like LSD, psilocybin mushrooms, DMT, mescaline, and peyote.

What does a 10 panel drug test consist of? ›

Standard 10-panel test: typically looks for cocaine, marijuana, PCP, amphetamines, opiates, benzodiazepines, barbiturates, methadone, propoxyphene, & Quaaludes.

What is the most common pre-employment drug test? ›

Urinalysis – A urine test is the most common form of pre-employment drug testing and is typically conducted once a conditional offer of employment has been sent.

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